Welcome to the Gutruf Lab
The Gutruf Lab
Our research focuses on creating devices that intimately integrate with biological systems. We combine innovations in soft materials photonics and electronics to create systems with broad impact on health diagnostics and neuroscience.
News
Chronic Biosymbiotic Electrophysiology
Happy to share that our paper on Chronic Biosymbiotic Electrophysiology has been published in Advanced Functional Materials.
This work demonstrates the integration of conductive carbon-doped TPU into textiles for electrophysiological applications like ECG and impedance pneumography, and biosymbiotic devices for impedance myography. This approach eliminates the need for adhesives while maintaining high-fidelity, comparable to gel electrodes, the clinical gold standard. The textile integration ensures large area coverage with minimal motion artifacts, making it ideal for continuous ECG monitoring. Meanwhile, the biosymbiotic integration enables precise, localized interrogation, supporting advanced electrophysiological modes. The technology is, of course, integrated with our recharge at distance capabilities demonstrated in our prior work https://doi.org/10.1016/j.bios.2023.115218,https://doi.org/10.1126/sciadv.abj3269) which, combined, results in a multimodal electrophysiological platform that can operate 24/7 over many weeks without interruption or signal degradation.
Check out the paper below:
https://doi.org/10.1002/adfm.202407086
Comprehensive overview of implantable organ interfaces
Our comprehensive review article on Wireless Battery-free and Fully Implantable Organ Interfaces published in Chemical Reviews today.
The review covers all aspects of the technology class and features extensive statistics.
Congratulations to Dr. Aman Bhatia, Tucker Stuart, Kevin Kasper, Jessica Hanna and David M. Clausen.
We also publish the data used in the statistics throughout the article, for everyone that wants to do further analysis.
Biosymbiotic devices to combat the reduce digital health divide
In remote areas with limited connectivity, effective patient monitoring remains a challenge, often resulting in substantial healthcare disparities. In our most recent work we tackle the challenge with a seamless wearable device enabling long-range transmission of biosignals over 15 miles, integration of on-board biosignal computation, and remote wireless recharging to enable weeks of continuous operation.
Interested in a deep dive on the technology, find the article published in PNAS. For the quick read, check out the short media article.
Next-Gen Nervous System Interfaces for Spinal Cord Function Recovery and Gait Restoration
The next generation of nervous system interfaces is in the starting blocks, promising to recover spinal cord functions and make the paralyzed walk again. However, interfacing with this very mobile area of the body is tricky. In our newest work, we solve prevalent technological challenges to create seamless untethered interfaces with the spinal cord and muscles, demonstrating restoration of gait over weeks.
Ever wondered how we can make wearables that work 24/7 without needing to plug in or use a wireless charging pad?
Check out our newest paper in collaboration with Christophe Fumeaux`s lab that dives deep into Biosymbiotic wearable antenna design for wireless power casting.
Our groups review article is featured in the top 10 in APL Bioengineering
Check out the article here.
Work on context aware antenna design published in Biosensors and Bioelectronics
Check out our most recent work on behavior guided antenna design for wearables. With this design method, we demonstrate that you can recharge a wearable with a simple powercasting box on your table and transfer sufficient energy to run high fidelity and high sampling rate biosignals acquisition for weeks without touching the device.
Our work in Microsystems & Nanoengineering is nominated for the outstanding paper award
Our paper "Wireless, battery-free, and fully implantable electrical neurostimulation in freely moving rodents" was nominated for the outstanding-paper awards in Years 2021 and 2022, based on the ratings and comments from the paper reviewers as well as the associate editors during the paper selection process.
Lab Students Honored
An industry panel at the BME research day recognized 4 students from the Gutruf lab for their outstanding research work.
Our work on wireless and fully implantable electrochemical catecholamine sensing and neuromodulation is out today in ACS Nano.
This has been in the making for a long time in a collaboration across 4 universities:
Osseosurface Electronics - a permanent biointerface to characterize bone health, check out our newest work in Nat. Comm.
Our newest work published in Nature communications: "Osseosurface electronics—thin, wireless, battery-free and multimodal musculoskeletal biointerfaces" check out the scientific article and for a quick read head over to the College
Our work on Biosymbiotic electronics is published in Science Advances
Gutruf Lab highlighted in Nature Methods Technology Feature
Check out this Nature Methods Technology Feature on the frontier of Wireless Neuroscience Tools, our work is prominently highlighted.
Our work on chronic electrical neurostimulation is published in Microsystems & Nanoengineering
Check our our work on Wireless, battery-free, and fully implantable electrical neurostimulation in freely moving rodents.
Read our newest article on the first wireless optogenetic transcranial stimulators published in PNAS
Check out our newest article on Wireless, battery-free, subdermally implantable platforms for transcranial and long-range optogenetics in freely moving animals.